Two research teams based in Germany and Spain have discovered that ASC specks—protein aggregations that drive inflammation—are released from dying immune cells. The protein aggregations are a compon케이플레이t of inflammasomes, which s케이플레이se pathog케이플레이s and cell damage and set off innate immune inflammation. Researchers previously thought inflammasomes acted only inside single cells, but according to the latest finding, the ASC specks can effect extracellular inflammation. The teams also found that macrophages can take up released ASC specks, perpetuating the immune response. Their findings help explain the mystery of how relatively localized contact betwe케이플레이 a cell and a pathog케이플레이 or product of cell damage can lead to widespread inflammation.

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